She also won best pop vocal performance for Halo. Accepting that trophy, she said: "This has been such an amazing night for me and I'd like to thank the Grammys格莱美奖.
"I'd like to thank my family including my husband, I love you," she added, referring to rapper说唱歌手 Jay-Z.
But she lost out to输给 Tennessee rock band Kings of Leon in the record of the year category.
In a surprise result, the group's song Use Somebody won that prize, also beating hits by Lady GaGa, Taylor Swift and The Black Eyed Peas.
The song had also earlier been named best rock song - triumphing over tracks by heavyweights like Bruce Springsteen, U2 and Green Day - as well as best rock performance by a duo二重唱,二人组 or group with vocals.