But the quote above has nothing to do with modern-day athletics. It comes from a retired track coach quoted in a 1971 New York Times Magazine article. (The article's author, sportswriter and activist Jack Scott, who died in 2000, has one of the more interesting biographies you'll find-Oberlin College athletic director, Bill Walton confidant, onetime suspected associate of the Symbionese Liberation Army.) Whether or not the coach's statement then was somewhat hyperbolic, it's clear that the drug problem has loomed over the sports world for a long time. And although the abuses in cycling have become harder to ignore in just the past two decades, the sport has been home to all manner of chemical enhancements for more than 100 years.

Jacques Anquetil, a French cyclist who won the Tour de France five times in the 1950s and 1960s, openly admitted to doping. "Everyone in cycling dopes himself," he said in Scott's 1971 article. "Those who claim they don't are liars." In Anquetil's era, the agents of choice were stimulants such as amphetamines, but as early as the late 1800s cyclists fueled up with a mixture of coca leaf extract and wine called Vin Mariani, according to a 1983 Hastings Center report.

Baseball, too, had its period of rampant amphetamine use, which is viewed in an almost nostalgic light now that stronger performance enhancers such as anabolic steroids and human growth hormone have tainted the game's image. But in endurance sports such as cycling, performance enhancement can be especially deadly. At the 1960 Summer Olympics in Rome, a Danish cyclist named Knud Enemark Jensen lost consciousness during a race, fell from his bicycle and died. Postmortem tests reportedly revealed the presence of amphetamines in his system. After English rider Tom Simpson collapsed and died during the 1967 Tour de France, amphetamines were found both in his bloodstream and in a vial tucked inside his jersey.

More recently, cyclists have boosted their endurance with the use of an artificial version of the hormone erythropoietin, or EPO, which stimulates red blood cell production and boosts the oxygen-carrying capacity of the blood. Danish cyclist Bjarne Riis, who won the 1996 Tour de France, later admitted that he used EPO during that time.

EPO thickens the blood, and it also has proved dangerous. After a spate of suspicious rider deaths, a 1991 New York Times article highlighted the deadly potential of the drug du jour. "There is no absolute proof, but there's so much smoke that most of us are convinced," University of Oklahoma hematologist Randy Eichner told the newspaper. "You just don't get 18 deaths in four years, mysteriously, with 10 of them attributed to cardiac problems."

Cycling insiders, too, noticed drastic changes in 1991. That is the year that three-time Tour de France winner Greg LeMond thinks that EPO took over his sport. As he told Scientific American writer Michael Shermer in 2008, "Something was different in the 1991 Tour. There were riders from previous years who couldn't stay on my wheel who were now dropping me on even modest climbs." LeMond had won the race the two previous years, but he fell to seventh place in 1991.