The relative risk was calculated versus no supplementation in the same population
他们计算了相对风险对比相同人群中的未补充者
Not everybody of course did what they were
并不是所有人都服用
They were recommended to do under the circumstances
只有被建议的人才会服用
Here the differences are so striking that I have to resort to a log scale once again
差异非常明显,我必须使用对数刻度才能显示好
And what we see here is that
这里可以看到
88% lower risk of developing diabetes by age 31 in infants of that 2000 IU per day versus those who got none
每天服用2000IU的婴儿比没有服用的在31岁时患糖尿病的风险减少88%
And conversely those whose physicians thought they might have rickets because they had some of the physical symptom
相反,医生认为可能患有佝偻病的人
They had a three-fold increase in risk over those who just got no vit D in the process
是没服用维生素D的人的风险的三倍
There's a huge difference between 3-fold and 90% reduction, 2 orders of magnitude
三倍和90%减少之间差异很大,两个数量级
For reasons which have never been very clear to me that Finnish government backed away from this recommendation
所以我总搞不明白芬兰政府为何没遵从这个建议
and now they're down to a recommendation which is similar to that which the American Academy of Pediatrics now has recommended
现在他们采纳了一个类似建议由美国儿科学会提议
but I think, this is almost surely what's called an epigenetic effect that is we're changing which genes getexpressed
这应该就是所谓的表观遗传现象,我们改变了表达的基因
and that's being programmed very early in life both in embryo and in the first year of life
这在生命早期就已经设定好包括胚胎和一岁前
probably helping the lymphocytes to figure out the difference between self and non self and they don't quiteget it right,
也许帮助淋巴细胞区分自身和非自身,如果没搞对,
Then you run your increased risk of developing type one diabetes
患1型糖尿病的风险就会增加
Presumably something similar is happening with respect to multiple sclerosis and the other immune disorders
类似的也许还发生在多发性硬化及其它免疫功能紊乱