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维生素D，是一类脂溶性维生素，属类固醇化合物。在人类所需的维生素中，维生素D非常特殊，它是一种激素的前体，而且在阳光充足的情况下，人体自身可以合成。这一讲教授着重讲了维生素D同DNA作用，参与到蛋白质合成的原理，以及维生素D对癌症、糖尿病、骨质疏松、高血压等诸多疾病的预防及辅助治疗作用。
n. 钙
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- Now I want to show you a randomized controlled trial with respect to blood pressure
- 下面讲一个关于血压的随机试验
- This was published in Germany. Now nine years ago
- 9年前发表于德国
- I'm just amazed that nobody seems to know about it
- 我很惊讶，竟然没人知道它
- A perfectly good journal, Clinical Endocrinology & Metabolism
- 临床内分泌代谢杂志，它其实很棒
- 148 older women double-blind randomized trial
- 148名老年妇女，双盲随机试验
- The baseline 25D was below 50 nmol
- 基线25D低于50纳摩
- It's kind of typical of what we would find in the US and they were treated for eight weeks either with calcium alone or with calcium plus vitamin D
- 这和美国的典型值一样，治疗8周，部分只用钙，部分是钙+维生素D
- Modest dose eight hundred international units So, that was a pretty good dose for people back then
- 适度剂量 800国际单位，这在当时算不错的剂量了
- Back then, only eight years ago, nine years ago
- 当时，其实也就八九年前
- Now it's known that calcium lowers blood pressure
- 钙能降低血压
- We don't use it for the treatment hypertension because it doesn't lower it enough
- 这不用于高血压治疗，因为降低程度不够
- but at a population level that's been clearly established that you lower blood pressure with calcium usefully as a matter of fact
- 不过就公共健康而言这显然有用，补钙确实能降低血压
- but not therapeutically useful. So there's a difference there
- 只是不用于治疗而已，这有差别
- So the question was not so much that calcium do it but there's vitamin D add something to the calcium which would be better than the calcium alone
- 因此问题不是钙降血压这一事实，而是维生素D+钙是否比只用钙要好
- and what we have is simply an 8-week trial
- 这只是简单的8周试验
- This is one of those acute effects that you can produce very early on
- 这个效果很快就能显现出来
- The gray bars are the baseline values
- 灰色条形图是基线值
- for the calcium only group, for the calcium + D group
- 左侧是只补钙，右边是钙+维生素D
- And the open bars are the 8-week values at the end of the briefly treatment period
- 空心条形图是8周治疗后的值
- 5.7 millimeter of mercury drop from calcium alone
- 只补钙，降低5.7毫米汞柱，
- which I think you would agree with me is useful from a public health standpoint but may not be enough if you're treating a patient with clear hypertension
- 大家肯定赞同，这对公共健康有用，但对高血压患者治疗却不够
- So I guess I make that distinction
- 这有必要区别开
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| 重点单词 | 查看全部解释 | |||
| calcium | ['kælsiəm] | 联想记忆 | ||
| trial | ['traiəl] | |||
| hypertension | [.haipə'tenʃən] | 联想记忆 | ||
| distinction | [dis'tiŋkʃən] | 联想记忆 | ||
| acute | [ə'kju:t] | |||
| produce | [prə'dju:s] | 联想记忆 | ||
| population | [.pɔpju'leiʃən] | 联想记忆 | ||
| controlled | [kən'trəuld] | |||
| pressure | ['preʃə] | 联想记忆 | ||
| modest | ['mɔdist] | 联想记忆 |
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