5.Aquagenic Urticaria

4.Brainerd Diarrhea

As you can probably guess from the name, this disease is a severe, acute form of diarrhea first described after an outbreak in Brainerd, Minnesota. The exact reason for the contraction is unknown to scientists at this time, but it may be caused by the consumption of contaminated water or raw milk. Sufferers experience 10–20 episodes of explosive, watery diarrhea every day. Nearly all of the recorded outbreaks have taken place in the United States, though there have only been eight since it was first discovered.Brainerd diarrhea can last for months—even up to a year—with no respite for those afflicted because it's extremely resistant to any form of antimicrobial treatment. Drugs like Imodium have been reported to offer some relief, but only in very high doses. Because the exact source of the disease is unknown, there is no known preventative measure, other than to boil all well water and avoid unpasteurized milk.

3.Sickle Cell Anemia

Sickle cell anemia is a genetic blood disorder in which the red blood cells form abnormally, taking the shape of a crescent or sickle. In addition, there aren't enough blood cells to transport oxygen throughout the body. Those afflicted with SCA also lose the defective blood cells up to 12 times faster than those without the disorder.A mutation in one of the genes responsible for hemoglobin is the root cause of the disorder and it seems to be most prevalent among those whose ancestors lived in areas where malaria was common. The symptoms vary person to person, but fatigue and chronic pain is extremely common and never goes away. Thanks to modern medicine, it isn't the killer that it once was, with many people making it to their 60s and beyond. However, while blood and marrow stem cell transplants have shown some promise, there is still no cure.

2.Adiposis Dolorosa

For anyone familiar with Latin or the TV show Doctor Who, it will be obvious that this particular disease has to do with fat. Also known as "Dercum's disease" after the doctor who first described it, sufferers are plagued with tumors called lipomas all over their torso. Nearly all of those who get this disease are obese women between the ages of 35–50.With no known cure or cause, Dercum's disease is believed to perhaps have a genetic component to it, as it does seem to run in some families. Other scientists theorize that it is an autoimmune disorder, as healthy tissue is attacked by the body. Tthe only treatments available for this extremely painful condition focus on one symptom at a time, utilizing pain medications and weight loss strategies. Liposuction has shown some mild success at treating the disease.

1.Ondine's Curse

For those of you unfamiliar with French or German folk tales and mythology, Ondine was a nymph who took a mortal as her lover, who swore that each one of his breaths would be a testament of his love for her. After he committed adultery, Ondine—or her father, in some versions—cursed the cheater to stop breathing the next time he fell asleep. Otherwise known as "congenital central hypoventilation syndrome," sufferers lack the function of the autonomic nervous system which regulates breathing. This means that they have to consciously remember to breathe.When they sleep, most are hooked up to ventilators. If they are able to survive into adulthood, the sleep masks used to treat sleep apnea tend to work well enough to enable them to live relatively normal lives. Genetics are believed to play a major role as the cause of the disease, though it has appeared in adults after major surgery or trauma.

翻译：宁舒子 来源：前十网