run sth
管理；经营:
Stop trying to run my life (= organize it) for me.
别老想操纵我的生活。

ratchet (sth) up
(使)逐渐小幅增长:
Overuse of credit cards has ratcheted up consumer debt to unacceptable levels.
滥用信用卡使消费债务逐渐增加到了难以接受的地步。

take charge
主管；掌管；照管；职责；责任:
He took charge of the farm after his father's death.
他在父亲去世后掌管了农场。

set out
(怀着目标)开始工作,展开任务:
She set out to break the world record.
她一心努力要打破世界纪录。

replace sb / sth (with / by sb / sth)
(用…)替换；(以…)接替:
It is not a good idea to miss meals and replace them with snacks.
不吃正餐,改吃点心,这不是什么好主意。

discredit sb/sth
败坏…的名声；使丧失信誉；使丢脸:
The photos were deliberately taken to discredit the President.
这些蓄意拍摄的照片旨在败坏总统的名声。